Lymphogranuloma venereum, a sexually transmitted infection of bacterial origin, has long been considered a tropical disease. Nevertheless, its incidence in the developed world has been on a steep and constant rise since the early 2000s. In the course of the establishing epidemic both in North America and Europe, anal intercourse is the main way of transmission. The resulting condition, typically a primary proctocolitis may present with various symptoms. The authors herein present and emphasise the clinical characteristics of newly diagnosed cases at the National Centre of STIs between 2017 and 2018, which mainly presented with gastrointestinal symptoms. Overlooking them, thus delaying a diagnosis might result in serious public health consequences.

In this review article, the authors describe the epidemiology, clinical manifestations, diagnostics and therapy of bullous pemphigoid. They emphasize the role of drugs among the trigger factors and the atypical clinical presentations which occur with increasing frequency. Although the aging of population contributes to the currently increasing incidence and prevalence of bullous pemphigoid, this tendency might be in part also due to the widespread use of certain drugs and the fact that dermatologists do diagnose non-bullous forms with increasing frequency. Uncommon, atypical forms of pemphigoid are illustrated with a number of clinical photographs.
Further, the authors review both the diagnostic procedures and the up-to-date therapeutic guidelines which allow efficient treatment with only a few side effects and complications.

The development of novel medical imaging tools has resulted in significant progression in the field of dermatology.
However, histopathological evaluation still remains the gold standard diagnostic method. Novel, in vivo non-invasive imaging modalities can provide near histological resolution and can be applied in the assessment of various dermatological diseases. In this paper, the authors review the clinically applied imaging techniques among the newest experimental devices. After the description of the basic principles and imaging properties of these techniques, the authors also discuss their clinical applications.

Defining health has brought about the concept of quali ty of life, health-related quality of life and the need to measure them. Health-related quality of life can be measured by using general health, dermatology-specific and disease-specific instruments. Hungarian research groups have measured the health-related quality of life in many areas of dermatology, including psoriasis, psoriatic arthritis, pemphigus and morphea patient populations. Hungarian research on measuring health-related quality of life gives the opportunity to better understand the burden of the diseases, which may also contribute to clinical and financial decision-making in the future.

Authors analyzed the data of 357 patients patch tested in the Allergology Outpatient Unit and Laboratory of Dpt. of Dermatology, Venerology and Dermato-oncology of the Semmelweis University in 2017. Altogether 16.8% out of the patients were sensitive to at least one fragrance allergen. More females had been tested and more have had hypersensitivity reactions than men, however, the proportion of sensitised patients were almost identical in both genders (women: 16.5%, men:17.6%). Wood tar gave hypersensitivity reactions in 6.7% of the tested patients, Fragrance mix II (FM II) and balsam of Peru in 5.9%, Fragrance mix I (FM I) in 5.3% and colophony in 1%. We detected early test reactions typically for balsam of Peru. Most of the late onset reactions gave wood tar (24), but the FM II (20), FM I (19) and the balsam of Peru (18) showed similar results. According to the results 6.7% of all the test reactions developed only on the 7th day. Thirty-five percent of the sensitized patients showed positive reactions for more than one fragrance allergen. Among the combinations the connection of FM I and FM II was the most frequent. According to our data no discoverable correlation could be identified between the fragrance hypersensitivity and the profession of the tested patients.

The authors describe two cases with benign atrophic papulosis, the benign variant of Degos-disease, distinguished by the absence of systemic disease. Clinical picture, pathomechanism, differencial diagnosis and therapy are summarised.

The authors summarize the recent understanding of a rare, hereditary connective tissue disorder with multidisciplinary significance, vascular Ehlers-Danlos syndrome. Leading
symptoms of the disease – articular hypermobility, skin hyperextensibility and general tissue fragility – mainly impair quality of life, however they can lead to severe, fatal complications.
During genotype-phenotype correlation analysis the authors conducted extensive clinical examination, nonlinear optical imaging and molecular genetic tests. The identification of patients affected by Ehlers-Danlos syndrome in dermatology practice serves the determination of tasks in medical care and thus, the prevention of complications.

Cutaneous T-cell lymphomas are rare, mostly incurable lymphoproliferative diseases with an indolent course, which strongly infuence the quality of patients’ life due to subjective symptoms and reduce life expectancies due to systematization and mostly to infective complications. Treatment of this group of diseases is determined by the diagnosis and staging but is always inidividual. For the treatment of early stage, localized diseases, skin directed therapies are usually sufficient alone. Advanced cases should be treated systemically.
Brentuximab vedotin is an anti-CD30 monoclonal IgG1 antibody–toxin conjugate which was approved for the secondline treatment of CD30 positive cutaneous T-cell lymphomas
in January 2018. We share our experiences with our first two patients treated with brentuximab vedotin.

The number of hyaluronic acid fillers procedures has increased rapidly in the past years in Hungary as well as abroad. Hyaluronic acid is one of the most popular and safest substance used in aesthetic medicine to revitalize the skin and replace the loss of volume due ageing processes. The complications of the treatment are mostly due to incorrect material choice or injection technique and not to the hyaluronic acid itself. In the future a wider circle of medical and - because of the lack of regulation - also non-medical staff is likely to encounter these adverse reactions beside the trained and prepared aesthetics professionals, this is the reason why we would like to offer a short overview of the indications of hyaluronic acid fillers, and management of the complications.