Recently, in vivo mouse models have become indispensable tools for understanding the genetic, molecular and immune mechanisms contributing to the development of human diseases.
Modeling a complex, multigenic disease such as psoriasis in animal has proven extremely challenging for researchers and has several limitations. In spite of this over the last four decades, more than 40 mouse models have been
described for the investigation of psoriasis. In this study, we summarize the types of psoriasis-like model systems, their advantages and disadvantages.

Understanding the results of basic genetic research and how it could be applied in everyday healthcare, in other words translating it into clinical practice, is a challenging field for all of us. The ample information resulting from the methodological revolution of the last two decades is almost impossible
to follow and interpret on a daily basis. Even the most appropriate reviews from the filed rarely provide a clear answer to the questions raised both by psoriasis patients and clinicians: Will I have psoriasis? Will my psoriasis progress with time? Is joint involvement expected? How likely is it for my children to inherit the disease? Can we predict and prescribe accordingly the most effective therapy? In this review we aim to briefly introduce the methods used in the genetic studies and summarize their results that could be integrated
into our up-to-date answers to these questions.

Psoriasis is one of the best studied skin diseases. Interaction between keratinocytes, neutrophils, mast cells, T-cells and dendritic cells plays pivotal role in the pathogenesis of the disease. Feed-forward circuits among these cells mediated by various pro-inflammatory cytokines lead to the development
of the characteristic phenotypic alterations.
Therapeutic inhibition of the central cytokines, such as IL-17, IL-23 and TNF-a, represent the most effective anti-psoriatic treatment nowadays.

Psoriasis is a chronic immune-mediated skin disease with systemic inflammation. In the present study the authors introduce the clinical features of the disorder. Furthermore the histopathology of the disease as well as the leading co-morbidities defining the prognosis of psoriasis are reported.

Skin symptoms of psoriasis may vary in a wide range. Generalized
pustular and erythrodermic forms comprise the most
severe variants of the disease, often leading to hospitalization
or urgent medical attendance. Attention must be payed
to pustular psoriasis localized to the palms and soles, for its
therapy resistent behaviour. In this publication the authors
overview the latest consensus statement on the phenotypes
of pustular psoriasis. Clinical characteristics, current forms
of therapy, and possible etiological aspects of erythrodermia
will also be discussed.

The authors review the topical treatment possibilities in psoriasis. After a discussion of general treatment methods they present detailed descriptions of topical therapeutics that employ corticosteroids, dithranol, vitamin D analogues, topicals with fixed combination of agents and calcineurin inhibitors
along with their application in an everyday clinical setting.

Detailed new data on the immunpathogenesis of psoriasis changed our view on the disease and resulted in new treatment possibilities. Lot of new knowledge was gained about traditional antipsoriatic drugs as well, which also have
an increased importance in the era of biologicals. Reappraisal of treatment guidelines of moderate to severe psoriasis led to increased efficacy and less adverse events in the treatment.
Authors summarize the latest approaches of traditional psoriatic systemic drugs.

In this article we review the biologics that are avalible today or may enter the market in the very near future. Our aim is to provide an overview to all practicing dermatologists with special emphasis on the progress on this field and to summarize the experience we gained over the past 13 years.

Ultraviolet (UV) light is a form of electromagnetic radiation.
The beneficial effect of UV light for various skin disorders has been known since antiquity. In the treatment of psoriasis, it has been used for nearly a century. During the evolution of phototherapy, UVB has been the optimum wavelength
range for the treatment of psoriasis, the narrower spectrum of which is used to maximize the therapeutic effect, while reducing undesirable intense erythema. Major break-through in phototherapy over the last twenty years was the
emergence of targeted phototherapy devices that emitted monochromatic
UVB light. At the same time, photochemotherapy was used less, due to the increased risk of carcinogenesis.
Phototherapy is an easy to use, effective treatment method for psoriasis and it is usually well tolerated. Knowledge on appropriate application of phototherapy is important, it is a specific dermatological competence, even in the age of
biological therapies.

Psoriatic arthritis is a usually seronegative, chronic polyarthritis associated with psoriasis. Authors aimed to give a review of the pathogenesis and clinical characteristics of psoriatic arthritis. Stopping disease progression is of key importance to maintain or improve quality of life. Authors give an update on psoriatic arthritis including treatment options and recent recommendations.